Bear with me and I’ll get to the plain English, In Vitro and In Vivo Osteogenic Activity of Largazole
Due to their capability of modifying chromatin structure and thereby regulating gene transcription, histone deacetylases (HDACs) have been reported to play important roles in osteogenesis and considered a promising potential therapeutic target for bone diseases, including osteoporosis. We showed that the novel marine-derived HDAC inhibitor largazole exhibits in vitro and in vivo osteogenic activity. Largazole significantly induced the expression of ALP and OPN. The osteogenic activity of largazole was mediated through the increased expression of Runx2 and BMPs. Importantly, largazole showed in vivo bone-forming efficacy in the mouse calvarial bone formation assay and the rabbit calvarial bone fracture healing model. The dual action of largazole to stimulate bone formation and inhibit bone resorption would be a useful feature in drug development for bone-related disorders.
Researchers investigating some cyanobacterium which lives naturally in coral reefs found a type of chemical called a Largazole. Largazoles have already been fund in other organism including land snails, some trees and scorpion venom. Quite a few modern medicines have been derived from the Largazole family. Some estimates put the number of Largazole medicines at fifty percent of commonly prescribed medications. Though none of those are from any Largazole derived from an ocean bound organism. Some researchers have already found coral reef Largazole might be an effective cancer fighting drug. In the instance of the coral reef cyanbacterium Largazole it does something else that is remarkable. It stimulates osteogenesis. Osteogenesis involves the growth of new bone and the repair of damaged bone. Your body – being your best friend and your enemy has a natural tendency to break down and absorb new bone. Largazole also seems to prevent that process from occurring. Bone damage and degeneration from aging pose serious health risks. Mix up a cocktail of Largazole, collagen and calcium phosphate, and bone tissue and scientists have found it helps heal fractured bone without the new bone being reabsorbed. So sure let industry, the Koch brothers and the conservative movement destroy all the world’s coral reefs because nature doesn’t matter, right? Tell that to the people with degenerative bone diseases.
Everyone has probably heard about this hoax by a protegé of James O’Keefe and yet another fake scandal promoted by Andrew Breitbart, Sex Ring Was A Hoax; Live Action Posts Video Targeting Planned Parenthood. This is an interesting piece of background on O’Keefe and the young woman who cooked up the Planned Parenthood hoax, Lila Rose Who Earned Her Video Sting Stripes With James O’Keefe At UCLA
Rose And O’Keefe “Received Criticism” For Their Deceptive Tactics, Which O’Keefe Called “Justified.” The Los Angeles Times reported:
O’Keefe, 24, said he and Rose have received criticism from some of their associates for using deception. “It’s a pretty complicated ethical issue,” he said, “but we believe there is a genocide and nobody cares, and you can use these tactics and it’s justified.” Rose and O’Keefe visited their first clinic — UCLA’s Arthur Ashe Student Health and Wellness Center — in 2006. They videotaped an employee telling them “some pretty bad things,” said O’Keefe, including that the fetus is a collection of cells. “That’s what set us in motion.” [Los Angeles Times, 4/26/09]
Going back to the old guard Right like the John Birch Society ( they were so far Right they though Nixon was in cahoots with Chinese communists) runs the morally reprehensible concept of the justified lie, the justified hoax, the justified character assassination, the justified urban political myths ( the Clintons murdering Vince Foster). There seems to be some microscopic awareness on the Right that much of what they say and do is immoral, but since these acts are done for the sake of this greater cause, it is all justified. Everyone who believes something or in something thinks they are right. The wiser ones also have some sense of humility, mercy and is less flinching in looking at the unvarnished facts. Historically, Conservatives and zealots in general think they are the chosen, the sole guardians of society’s stability and institutions – see Orwell’s Nineteen Eight-Four and Winston Smith whose job it is to constantly reinforce the propaganda from the Ministry of Truth.
Autumn Sun by Egon Schiele. Egon Schiele June 12, 1890 – October 31, 1918) was an Austrian Expressionist painter. Though he is often associated with the art nouveau movement.
Reclining Woman with Green Stockings 1917 by Schiele. Like a lot of artists male or female, or most people for that matter, Schiele seemed to be both attracted to and repelled by sex.